In addition to childcare, Mother Clara and the Sisters acted as nurses during both the Austro-Prussian War of 1866 and the Franco-Prussian War of 1870. Their resulting actions spared them from being completely disbanded by the government during the Kulturkampf as they were declared a nursing order. However, the Sisters were no longer permitted to teach or recruit new women seeking to join the order.
Persecution caused by the Kulturkampf greatly influenced Mother Clara to send her Sisters outside of Germany to continue the teaching and care of orphans. After establishing houses in France and the Netherlands, Mother Clara felt confident in sending Sisters to the United States